March 31, 2020
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How to Activate Autophagy – TIPS with Christiaan Leeuwenburgh, PhD


Hey, good morning everyone. I wanted to
share with you a super treat.
You’ve been flipping out over the videos
that I’ve been sharing around autophagy
and I thought what better way than to
sit down with my friend and someone who
I have so much respect for, that’s been
truly at the forefront of autophagy, of
intermittent fasting, of resveratrol, of
the process of creating optimal health
as we age.
Dr. Christiaan, thank you I appreciate
being in your backyard at the University
of Florida here.
– Yeah I’m very pleased to
be here and a nice lovely setting in the
morning and we can talk about this self
devouring process of autophagy: the self
eating of the cell.
And tell us a little bit
about umm -You’ve been studying how we
perform at our optimal you know for over
20 years you’ve been researching and
sharing your amazing findings with the
world. What got you interested in a autophagy – can you just share with us a little
bit about that journey?
– Yeah, so initially I studied
antioxidant enzymes and a
small peptide called glutathione, which
is a very important intracellular
antioxidant. And umm I studied this in the
context with aging and in muscle and
performance of the animals. And umm so that
got my interest of course I had
wonderful mentors and I was fortunate to
do this work in at the University of
Illinois and University of Wisconsin.
-What was it about autophagy like where did
that sort of come in?
– Autophagy came in at
the University of Florida when I met
Bill Done and we did some work with
exercising animals and caloric
restricted animals and we were one of
the first to show that even with
exercise or reducing the calories this
autophagy process is turned on and helps
again this the cell to recycle and to
repair and become healthier and more
resistant against stress.
-So why just for the viewer, why,
why is autophagy so important?
-Yeah, so as we age, or even
as we’re young
proteins and DNA become damaged and they
turn over so we need very healthy
proteins and peptides and DNA and RNA.
And due to variety of stresses from
oxidative stress, to glycated stress
reactive nitrogen species. So, different
forms of stresses can damage those small
peptides or proteins so we need to
remove them quickly to get new healthy
ones in place of those. So, we can
optimally you know function in the cell.
-For you personally, I mean you’re – I’m
obsessed with the way you live your life
and I’m always trying to emulate and
learn from you, so you know I’ve had the
privilege of running stadiums with you
in a very different way. But, how do you-
When you wake up in the morning, how do
you think about autophagy in your own body
and activating it?
Yeah, I first thing I
think is not to go eat immediately and
try to move now that doesn’t mean every
day I do that and some days I I fast and
we’ll talk about that. So this autophagy
process gets turned on when you’re
actually fasting or not eating. Umm so, I wait
I try to move, I’m here in a little my
little oasis. I can swim or do some
exercises and get going, maybe drink some
tea some of the compounds in tea can
stimulate it even more. And then I think
later on about movement and exercise, so
that’s a one thing I do.
– So the exercise, the compounds, and the tea…
and those things for you, you know. You’re
like I’m stimulating via talk to key
within my body.
– Absolutely, and umm, you know
again on the other -and we need to
have periods of fasting, as well on the
base that we’re maybe not exercising. And
one simple way there’s various ways you
can do
is to again have a very light breakfast:
Banana, peanut butter sandwich- not have
lunch, and then have you know dinner at
normal time: Six o’clock. And again you
overnight, before that, you didn’t eat. So,
you have quickly a period of time of sixteen
plus hours, where you have a very low
caloric intake. Umm during this time,
obviously, you need to be careful and hydrate
and you can have a treat like a piece of
chocolate nothing wrong with that,
because some of the compounds in there
are also shown to be beneficial.
I had a piece of chocolate yesterday. And
you know, I was born in Switzerland,
you’re from the Netherlands,
and I think you know – we know I my
grandmother taught me at a very young
age, like have a piece of dark chocolate
every day and there are so many good
nutrients- compounds in it.
– Yeah, you know…
epicatechins are in there and flavanols.
And umm yeah, especially when the body has
actually very little during these
fasting periods, you take some of those
compounds, it stimulates it even more. In
fact, one study in the heart, we showed
that caloric restriction plus
resveratrol is having an effect. Where
caloric restriction alone in the, in the
old hearts was not as effective. So as we
get old, certain pathways to turn on autophagy biological pathways are not optimal
and they need a little help from time to
time. So, combinational, combinational
types of therapies and treatments are
going to be the future.
– So, interesting that you brought up resveratrol.
So it was a decade ago that I read- and I read
an article in a local newspaper, where
Dr. Christiaan had done a study on
resveratrol and that was the light bulb
for me that got me so excited to go down
that pathway. And I went to the South of
France, and I worked with the University
of Bordeaux, and I really got passionate
about all the polyphenols found in the
red grape. But tell us about that study
on the sirtuins and resveratrol and maybe
just break it down
like to a simple level and why you got
interested in resveratrol in the first
place.
– Yeah so, you know others have made
some remarkable discoveries. Like David
Sinclair on the mechanisms and before
that there was the French paradox, where
people that actually eat a lot of fatty
cheese, fatty food, and high caloric intake.
And they drank wine- they had a lower
incidence of cardiovascular disease. So,
people start thinking about what is it,
possibly in the wine? I think maybe it’s
the cheese, you know? But it’s something
in the wine and quickly people found the
compound resveratrol. And both from long
longevity studies, in variety of species
from worms, mice, and mechanistic studies
in cells they were able to pinpoint that
it stimulates sirtuins.
Which are –
– Yes, explain what sirtuins are.
– Well sirtuins are a
family of proteins. And there’s many of
them that have a wide variety of
functions to tell genes to wake up and
to activate, and make certain protective
proteins- to further help and protect the
cells. So, they’re central they’re like a
master gene of aging, to keep a cell very
healthy and optimizing. But again, it’s a
signaling protein that helps to generate
other proteins that are important for
health. And some are compounds like you
know epicatechin I mentioned,
resveratrol, vanilla. Umm you know compounds
in tea. I’m drinking tea right now. But
they can also turn and increase your
energy indirectly by making more
mitochondria, by turning on another
master gene, which is PGC-1alpha. So
yeah, we want metabolism, we want healthy
mitochondria, and we want to turn those
over as well. And, and repair and remodel
those.
– So, by incorporating resveratrol,
the epicatechins found in things like
dark chocolate… the different
antioxidants found in the tea, the
different compounds.
These can all sort of help to switch on
and trigger these sirtuins?
Absolutely. And again, what I
mentioned earlier as well
is your biggest intervention still are
going to be exercising, chloric
deprivation from time to time in
combination with those
– Yeah
I think is optimal.
So both nutrition, lifestyle
changes are going to be critical. To
optimize this process.
– Exercise. Tell us a
little bit about what exercise means to
you, and how we can simply incorporate it.
– Yeah, so you saw my gym earlier. There’s no
equipment.
So, it’s a play gym that your
daughter shares with you right?
– Yup.
– It’s very cool. I like, I like this idea
it not being like a structured.
– Structured. Yeah, I’m not a favor.. in favor of
structured. I bike to work. So normal daily
activities: walking, biking, playing, gardening… Those
are going to be again, in my belief
your foundation and then in addition
some strength training. Now I get some
strength training with my daughter
because we do a lot of you know balance
and would play around a lot.
That’s really exciting and good news. You know,
for everybody to think of it where we
just move in our day and we play and we’re…
– Critical, critical
– Yeah.
And you know we are modern
humans. And this is a good and
a bad thing. We have a lot of
conveniences of daily life. We sit in
front of computers. That’s what I mean
with the modern, modern human. They’re
very inactive during the day, so it’s
important during the day to find breaks
to stimulate metabolism. Again, we didn’t
talk much about the overall goal is to
motivate and stimulate metabolism at the
right time. Umm, of course we talked about
exercise and, and, and restriction of
calories, but if you’re exercising a lot,
sure! You need to eat. And I I love food I
eat a lot don’t get me wrong. So, you have
to have that balance.
We talked a little earlier about
circadian biology and circadian rhythms.
And you want to keep those very balanced
as well, because they will help with autophagy.
And if you disrupt that, the autophagy
won’t work and what is the circadian
biology is we have clocks and there’s
some very famous professors here at the
University of Florida, like Karen Esther,
who’s studying this. And you don’t want
to disrupt those clocks. And how can you
make sure you don’t disrupt them again
regular being very rigorous and when you
go to bed, when you eat, and when you move.
And you need to keep that in tune as
well, so that helps metabolism.
The circadian rhythms and, and you know I
understood that every single cell in our
body… just like every single cell has, has
the ability to activate or deactivate
autophagy it also has a little clock within
it. And a 2017 Nobel Prize was in
circadian rhythms.
Yeah it’s an absolutely
you know hot topic and it
makes total sense. And you know they’re
finding you know everything: plants-
anything has clocks. And it responds to
light.
– Yeah.
– And again we talked earlier
about light. It’s important to wake up
and get it get a good pattern of life
people are afraid for light, but we need
light to live and to keep the clock in
balance. So it’s important to go outside
and, and move there as well, and get
exposure.
– I have you know very strong
feelings on the benefit of light and us
being in the Sun. And just curious, for
you, how much time do you spend in the
Sun? And are you putting things like
sunscreen on, or are you letting your body?
– Absolutely. I put sunscreen on. My
wife is very good about this. And I
I think about 15-20 years ago I made
sure I was better protective. I wear
long sleeve shirt. But it’s okay for 20-30 minutes to
take, to take the shirt off
and get some exposure with some
sunscreen. But I think- yeah, light is
critical. And you know if people don’t
get exposure that’s going to be not only
vitamin D, but it’s gonna have more
effects on the cell, which has to do with
circadian biology, which can then affect
autophagy as well.
– So cool. Dr. Christian I am…
for me, it’s an honor to be able to come
over to your house in the morning on the
way to work. You’re you’re flying off to
Dubai today… a world-renowned expert.
You’ve dedicated your life really to the
biology of Aging. Your work of the aging
Institute and to be able to have the
privilege to pick your brain for a
couple minutes this morning it’s just
it’s like a dream come true.
It’s like a dream come true and I
truly can’t thank you enough.
– Thank you and you know my goal is to
optimize like we discussed earlier…
everybody’s maximum potential at every
decade. And optimize our health span and
our performance. Doesn’t matter how old
you are. It’s very important for me to
help with that, and to give people
information on the basic science side to
optimize this.
– Well you’re incredible. And again,
thank you so much for the opportunity to learn.
– Thank you Naomi, it’s great pleasure.

Randall Smitham

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85 COMMENTS

  1. Naomi Whittel Posted on June 1, 2019 at 3:04 pm

    My special thanks to my friend, Christiaan for being so generous with his time and knowledge. So much more to come soon on this fascinating subject. Be sure to check out the description for other video links on autophagy as well as other learning resources. Also, we are planning to devote many videos to this subject so if there's anything you would like us to focus on or an area you'd like me to explore please feel free to suggest future video ideas and we'll do our best to make it happen. Thanks for watching! 🙂

    Reply
  2. Karina Gomez Posted on June 1, 2019 at 3:49 pm

    Thank you Naomi for this amazing information!

    Reply
  3. Keto Mama Posted on June 1, 2019 at 3:49 pm

    A banana PB sandwich not keto/ low carb ???

    Reply
  4. Carol Gilmour Posted on June 1, 2019 at 4:00 pm

    What brand/type of tea is it 🤔

    Reply
  5. AH HENG Posted on June 1, 2019 at 4:18 pm

    Keep updated information on aging gracefully & living to fullest for All of us! I thank you from bottom of my heart

    Reply
  6. Monica Martinez Mulkerin Posted on June 1, 2019 at 4:27 pm

    Wow! Thank you 😊

    Reply
  7. Novmacar Posted on June 1, 2019 at 4:28 pm

    I wonder what sun screen he uses as most sunscreen stops Vitamin D production.

    Reply
  8. Clint Vincent Posted on June 1, 2019 at 5:23 pm

    What’s his choice of tea?

    Reply
  9. Elizabeth Posted on June 1, 2019 at 5:25 pm

    What kind of tea?!!!!

    Reply
  10. Jake Bildstein Posted on June 1, 2019 at 9:04 pm

    you need to look at the camera more it will make the viewers feel more involved. lol

    Reply
  11. The Map Of You Posted on June 1, 2019 at 9:20 pm

    The doctor is looking at her thinking! Maybe i should interview her cause she looks way young and knowledgeable herself lol

    Reply
  12. 1icestone Posted on June 1, 2019 at 9:49 pm

    Naomi , i know you are on a keto diet but what are your thougths about raw food vegan
    Almost if not all the people i checked on youtube that are on it for a loooog time they look teenage like face , even old people
    since the protein is so low on Raw vegan , i guess autophagy is not a choise for the body but a must to recycle old protein
    Raw vegans have very little loose skin after weight lose (i supose autophagy) very little wrinkles on their face as well , most have almost red tight glowing skin , probably all the vitamin c in the raw fruits and vegies that helps with building colagen
    i love your passion in all you do
    thank you

    Reply
  13. Paul Doran Posted on June 1, 2019 at 10:31 pm

    12 hrs fasting not enough.. Unless you enter ketosis, not much benefit. I do 23 hrs a day (OMAD) plus an extended 30 hr fast 1x per week. I excercise at the end of my fast. Ketosis every day

    Reply
  14. sharad shukla Posted on June 1, 2019 at 10:51 pm

    Thanks naomi for very useful knowledge.

    Reply
  15. Mike Affholder Posted on June 1, 2019 at 11:52 pm

    Thank you!

    Reply
  16. Krutarth Bhatt Posted on June 2, 2019 at 12:56 am

    Can you do one ten day water fast where you show blood test results,it will be helpful for viewers,we can understand the true power of self healing.

    Reply
  17. anj patnaik Posted on June 2, 2019 at 2:12 am

    I like your videos Naomi and I sense you're a very humble person.

    Reply
  18. Sadaf Sarwar Posted on June 2, 2019 at 4:48 am

    Good job Namomi Mittal ,I love your all video it's very knowledgeable.autophe G is my favourite topic because I m Muslim when I fasting in Ramadan I was always curious why fasting in Islam but autopheG gives anwer this is best for human.And anyone known about autopheG

    Reply
  19. Marlo Webster Posted on June 2, 2019 at 6:48 am

    Thank you both. I’m working on being fit and fabulous beyond 40 and truly grateful for the information shared.

    Reply
  20. Ser, más que tener Posted on June 2, 2019 at 7:48 am

    child like spirit & movement juggled with military precision of good daily habits 😉

    Reply
  21. Phil Jermakian Posted on June 2, 2019 at 9:42 am

    12:20 exactly why New York has had a blanket of chemical neurotoxin sprayed over it for the past 5 years or so.

    Reply
  22. catherine moore Posted on June 2, 2019 at 10:32 am

    what tea exactly is he referring to?

    Reply
  23. aniccadance13 Posted on June 2, 2019 at 10:34 am

    ‘Light breakfast with peanut butter sandwich’ .. well after that I wonder why I started listening to this in the 1st place.
    Btw I’ve been doing IF for over 3y now..

    Reply
  24. Anne Lang Posted on June 2, 2019 at 10:37 am

    How do you optimise your circadian rhythm when you work nights and when is the best time to eat?

    Reply
  25. Pyramid Vlogs Posted on June 2, 2019 at 11:00 am

    Really interesting

    Reply
  26. Shirley Moore Posted on June 2, 2019 at 1:06 pm

    What sort of tea ?whats the best chocolate

    Reply
  27. Cookiefish Glubbb Posted on June 2, 2019 at 1:35 pm

    how old is he?

    Reply
  28. Bliss WKC Posted on June 2, 2019 at 1:47 pm

    Thank You so much dearest 💐
    You’re such an inspiration 🥰
    Be Blissful Eternally 🙏😇

    Reply
  29. Jim G Posted on June 2, 2019 at 2:46 pm

    Doesn't sun screen block the benefits of the sun? What about the chemicals in the sun screen?

    Reply
  30. C D Posted on June 2, 2019 at 2:52 pm

    So is he saying while fasting u can have a piece of dark chocolate n it won’t break yor fast?

    Reply
  31. Pengfei Cao Posted on June 2, 2019 at 2:53 pm

    As a cell biologist studying endomembranes and nutrient sensing, AKA this field, often found it amusing when ppl talking on could after mentioning one two magical terms

    Reply
  32. jorge pearl Posted on June 3, 2019 at 1:16 am

    spermidine promotes autophagy, same as resveratrol, so I want to eat both, as I make a 4 day water fast, the doctor said only about resveratrol, to eat it during the fast, only fasting is not enough

    Reply
  33. njhoxsey Posted on June 3, 2019 at 1:58 am

    It would help just to explain what exactly to do.

    Reply
  34. Helen Gooderham Posted on June 3, 2019 at 4:55 am

    Circadian rhythms, what about people who must work night shifts.

    Reply
  35. Sway P Posted on June 3, 2019 at 9:13 am

    What age is he ?

    Reply
  36. Ronaldo Effect Posted on June 3, 2019 at 10:18 am

    SIMPLY fast and enjoy the benefits !!

    Reply
  37. Mustafa Baris Posted on June 3, 2019 at 11:21 am

    So , basically , eat two meals a day , do the 16 hour intermittent fasting , exercise regularly and watch your circadian rhythms , get exposed to daylight by being outside and you probably will never visit your doctor ..

    Reply
  38. PeaceWillCome Posted on June 3, 2019 at 8:24 pm

    He’s wrong about using sunscreen. All the other info he gives is great though. 😊

    Reply
  39. Watson Clerk Posted on June 4, 2019 at 12:53 pm

    I was surprised to hear he uses sun screen.

    Reply
  40. Tommy Huynh t_wrex_mtb Posted on June 6, 2019 at 4:05 am

    This is a great video thank you for spreading the word. I started Intermittent Fasting July 15, 2017 I been eating only eat one meal a day (OMAD) for almost 2 years now. I was 176 pounds with 34" waist. I lost 30 pounds in first 3 months and kept it off since then. My waist is now only 28" and I weigh 146 pounds. I started fasting to lose fat but I will continue to eat one meal a day for the rest of my life due to all the health benefits especially Autophagy. I run into so my friends who don't recognize me now that I lost so much weight. So many people asked me how I lost all my weight so I made videos about my diet and work out on my channel. If you are thinking about Intermittent Fasting I highly recommend it.

    Reply
  41. biological Health Posted on June 6, 2019 at 6:49 am

    Wow, Amazing. He has perfect skin, Full Hair, No Grey Hair and Face Perfect complexity and he is 75 years old. wow. Shut the fuck up and get the hell out of here idiot. Naomi, what is happening to you?

    Reply
  42. Penélope Lavender Posted on June 12, 2019 at 12:34 am

    I never even heard of this. I feel like I've been living in a bubble. Thank you so much for the research

    Reply
  43. S C 1949 Posted on June 14, 2019 at 10:34 am

    What….Banana & Peanut butter sandwich!

    Reply
  44. Magen Kho Posted on June 20, 2019 at 10:58 am

    Most excellent straghtforward caring practical information about the benefits, and how to be motivated to start autophagy without fear. Thank you so much!

    Reply
  45. Deja Prescott Posted on June 20, 2019 at 7:57 pm

    what are the more common teas that help stimulate autophagy? green tea and earl gray?

    Reply
  46. Colin Murphy Posted on June 21, 2019 at 5:23 am

    The french paradox has been debunked. I was looking for how many hours to fast before autophagie activates and it was never specified in 15mins.

    Reply
  47. Lalas Raft Posted on June 21, 2019 at 5:30 am

    great video and interview , gracias Nao

    Reply
  48. Optimism 111 Posted on June 22, 2019 at 12:34 pm

    Hi have you heard about astaxanthin?

    Reply
  49. Miss Algorithm Posted on June 28, 2019 at 6:15 pm

    Yoshinori!!!

    Reply
  50. Jason Gray Posted on June 29, 2019 at 9:31 pm

    so its not good to intermittent fast everyday?

    Reply
  51. martin sinclair Posted on June 30, 2019 at 2:23 am

    Got a question for you. I've done a few three and five day fasts. Looking to get rid of some eye bags. How many fasts do you think would be required to get rid of them? I am thinking maybe 4-5 ten day fasts.

    Reply
  52. TheSweetScientist Posted on June 30, 2019 at 7:08 am

    You're so beautiful, Naomi. How old are you?

    Reply
  53. Edward Tobar Posted on June 30, 2019 at 9:06 am

    What if your a night shifter?

    Reply
  54. WD Wysong Posted on June 30, 2019 at 12:36 pm

    Super interview. Thanks!

    Reply
  55. Derpy Wolfie Posted on July 1, 2019 at 1:22 am

    Autophagy starts day 4 into continuous water fast. The rest of things don’t really work just advertising to buy expensive supplements.

    Reply
  56. Linda Molenaar Posted on July 1, 2019 at 9:02 am

    Great interview, thank you Naomi!

    Reply
  57. Dorothy Oputa Posted on July 4, 2019 at 11:48 am

    Nice video, thanks for sharing.

    Reply
  58. SANDRA BABU Posted on July 6, 2019 at 7:15 am

    very informative and inspiring video ,and very much excited to know more about the dual role of autophagy in cancer , that is in healthy cells as a tumor suppressor mechanism by preventing the accumulation of damaged organelles and aggregated proteins
    , and in established tumors as a key survival mechanism.

    Reply
  59. Curtis Quinntin Phelps Posted on July 10, 2019 at 3:00 am

    You know I am near sixty and I understand this guy is 75 yrs old. I believe whoever is talking or being interviewed should well state their age. Because if this guy is younger then 75 I would stop the show right away but at 75 he appears to be in nice shape and I can tell he gets around easily… very important. I look forward to seeing and hearing the truth of aging. Let us not fool each other. We are all in it to win it! Thank you Naomi for such vital information

    Reply
  60. Karen H Posted on July 17, 2019 at 10:16 am

    Hopefully someone can help answer this. Does fasting (intermittent and longer term) always put you into Ketosis? I have found out for prostate cancer you do NOT want to go into ketosis. It raises the PSA exponentially! So instead of all the great foods on keto, it will be a veggie, fish, low fat diet BECAUSE PCa, unlike most other cancers finds its food/ energy through fats and proteins, not sugars! Ugh. Also autophagy can be good, but alsp bad for PCa causing cancer cells to grow in number, not necessarily eat up the old cells and help the body produce new 'good' cells. Unfortunately it can go either way, but we can't know. On the other hand, I could use the keto diet for what aisles me. But I can't cook 2 different ways, so I'll have to go the veggie/fish route. I'm sorry I don't have links, as I just discovered this, but the book, How to Starve Cancer by Jane McLellen is a good start.

    Reply
  61. Darlene Snyder Posted on July 21, 2019 at 11:39 am

    What kind of sunscreen should we use? I’ve heard the most popular ones are filled with dangerous chemicals? And I have recently heard that coconut oil coffee oil contains spf of a 5? Curious of your thoughts or if anyone can advise here? Thank you!

    Reply
  62. Wayne Rogers Posted on July 22, 2019 at 3:19 pm

    What is unclear to me is how to determine when we are experiencing a state of autophagy. Advice please?

    Reply
  63. gorilla twist Posted on July 25, 2019 at 4:48 pm

    do not eat peanuts. eat only between 12- 6.

    Reply
  64. Bunny Biedenharn Posted on July 29, 2019 at 6:22 am

    Did he say VANILLA stimulates autophagy? If so, that's great news. As for Resveratrol, I'd sure like a trustworthy noncaloric source. We bought a bottle of Resveratrol capsules, which turned out to have been from a "wildcrafted" source – meaning they smelled like smoke – and by "smoke", I mean nasty, toxic, cooked over burning plastic. Normally, we compost things like that – but this was so vile, it went straight into the trash.

    Reply
  65. Aldo N Posted on July 30, 2019 at 3:07 am

    Very good video. I agree, I am 59 do cycling road bike and weights, get sun light without sunscreens (they are the ones that gives cancer) and yes have your wine and dark chocolate!!

    Reply
  66. ElmwoodParkHulk Posted on July 31, 2019 at 1:08 am

    Something also to look at while people were drinking wine they also had cheese which is known for K2 which is also excellent for heart health

    Reply
  67. Marina Raj Posted on August 4, 2019 at 5:20 pm

    Is it ok to have something like vitamin C and Glutathione while intermittent fasting? I saw another video that discouraged antioxidants like Vit C to be taken during fasting.

    Reply
  68. Jorge carrejo Posted on August 6, 2019 at 6:37 pm

    Is he vegan?

    Reply
  69. 2dogarage Posted on August 11, 2019 at 2:30 am

    Funny to hear someone talk about the importance of sunshine who also advocates poisonous sunscreen, makes no sense to me…

    Reply
  70. Jerry Sharp Posted on August 13, 2019 at 7:26 pm

    Daniel chapter 10…. a 21 day planned fast.by Daniel. No accident. Been around thousands of years… A lost science.

    Reply
  71. Chug-A-Lug Doug Posted on August 14, 2019 at 1:26 am

    The best way to avoid cancer and diabetes is to steer clear of fast food – processed foods. It is poison to your body. Google sugar industry paid $50,000 to Harvard researchers.

    Reply
  72. Robin Aberg Posted on August 15, 2019 at 5:27 pm

    He has no concept of lowering insulin. Banana? No thanks. Peanut butter sandwich? No thanks. This wasn't informative, sorry. Best of luck.

    Reply
  73. Saging Sabah Posted on August 17, 2019 at 3:59 pm

    I too do omad . I lost 7 kg in less than 2 mos. i fast 24-27 hrs and then i eat anything i wanna eat.

    Reply
  74. Khult Herro Posted on August 22, 2019 at 1:23 pm

    Just take how would lion start its day. No food upon waking, take walk to hunt, exercise by chasing, but no food.
    Sometimes a day or a few without eating, but still chasing and walking. So, fasting and exercise on intermittent and random scheduling. I am 60 years old and people think I am 40.

    Reply
  75. Ivan8er Posted on August 23, 2019 at 9:47 am

    Very good info on autophagy, but sun screen! You’re going to put a chemical on your skin that has been shown to cause DNA damage when exposed to the sun, and block the light required to make vitamin D. Forget studying autopagy, and study light, the people most prone to skin cancer are those who stay indoors. Doctors in Queensland Australia has pushed sun screen and the people have listened. Their skin cancer rates are through the roof. It’s not the sun that causes cancer, it’s the lack of sun.

    Reply
  76. Farmer Dude357 Posted on August 26, 2019 at 12:29 pm

    Welcome to America. Here we have all kinds of junk food. Thanks to the fda we got plenty of sugars and fake foods to stimulate the body.

    Reply
  77. periuk tembaga Posted on August 28, 2019 at 1:24 pm

    At 5:38 ".. caloric restriction plus (what?) … i did not catch the phrase

    Reply
  78. Ralph Hardie Posted on August 31, 2019 at 12:37 pm

    Bad sound…..duh… 5bucks for a clip on Mike.

    Reply
  79. spiral out Posted on September 4, 2019 at 1:34 am

    Chocolate fast huh?

    Reply
  80. Pep Legal Posted on September 4, 2019 at 4:09 pm

    He is 96 already … and looks pretty young for his age. Definitely Autophagy is the Way !

    Reply
  81. GianniVHL Posted on September 5, 2019 at 12:34 am

    Thank god for this guy. All the other "experts" and Drs on youtube make it seem like you will get a terminal disease by eating a banana or peanut butter.

    Reply
  82. Yaacov Posted on September 10, 2019 at 7:52 pm

    Naomi, what do YOU think of sunscreen?

    Reply
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